A group of Italian researchers investigating industrial hemp came up with two new cannabinoids: THCP and CBDP. The study was published in Scientific Reports on December 30, 2019.
What is the reason this is such an Important Deal?
THCP was found to have 7 links of a side chain that has not been previously seen in a natural cannabinoid. THC is a 5-link side chain. Two additional links enable THCP to bind more efficiently in the CB1 and CB2 receptors.
- THCP had 33 times the activity of THC
- THCP was 64 times more active than THCV
- THCP is 13x more potent than the recently discovered cannabinoid THCB against the CB1 receptor
- THCP has a higher lipophilic content (making it easier to dissolve in and mix with fats)
In the words of the researcher Dr. Cannazza, his research team was able to discover the discovery of THCP specifically “because nobody was searching for these compounds.” The research revealed the presence of phytocannabinoids THCP and CBDP within the strain supplied by the Italian government. The team has no idea whether or not and how many other chemovars create the two cannabinoids.
It is believed that the discovery of THCP could be why certain strains with low concentrations of THC are more potent for both their effects on psychoticism and their therapeutic effects. You can buy THCP products online from the best and most reliable shop, CannaAid Shop.
Metabolomics and Mass Spectrometry
Dr. Cannazza's group used metabolomics to study FM2's strain. Metabolomics is a method of measuring metabolites that combines mass spectrometry and chromatography separation. It results from a pattern that can be interpreted in a digital reading of an individual's state of health, which can determine their health status.
Metabolomics can precisely measure the body's reaction to cannabis treatment and usage. Examining individual metabolites can reveal the changes in the body before and after the use of cannabis about potential changes in neurotransmitters and natural endocannabinoids.
Mass spectrometry is a method of analysis that describes the chemical and structural properties of particular molecules. It is a method of identifying unknown compounds and measures the presence of known compounds in the sample.
The role mass spectrometry plays in ensuring the safety of cannabis testing is the following:
- Pesticide residue analysis
- Heavy metal level
- Mycotoxins derived from bacteria
It can also be utilized to determine the effectiveness of cannabinoids and the terpene profile of a specific strain.
The study's findings reveal that percent of THCP was lower than the percentages of THC in the plant both in vitro and in living. The two compounds seem to possess cannabimimetic properties that interact with CB1 receptor activation far over the stimulation by CB1 or CB2 receptors present in THC when it is in its decarboxylated version. Because of the greater engagement of THCP and those CB1 receptors located in brains, users might experience extremely potent and intoxicating effects.
The Italian team employed mice models that showed that the binding power for THCP upon CB1 receptors produced physiological and behavioral effects similar to THC with a half dosage. The products include an increase in hypomotility (deficiency or lack of motion) and a decrease in rectal temperatures, an analgesic impact, and catalepsy (a trance state in which one's limbs are in the same position they're put.) The strong binding can help clarify why certain chemovars containing THCP can give substantial therapeutic relief more efficiently than THC alone.
The other member, Dr. Citti, is confident that THCP and CBDP are essential for medical purposes; however, more research is required to determine the benefits and dangers of using these cannabinoids. He anticipates the growth of cannabis strains that are THCP-rich when the pharmacological characteristics of THCP are identified.
A side note: this Italian team also discovered CBDP. Cannabis researchers have found that CBD does not explicitly bind effectively in the presence of CB1 or CB2 receptors. As with their chemical structure THCP and THC, CBDP has a seven-link side chain, whereas CBD has a five-link side chain. If you want to buy THCP products online, check with Cannaaidshop. Try Now!